Soy Derivatives for Control of Hot Flashes in Men on Androgen Deprivation Therapy

A Prospective Trial of Soy Derivatives for Control of Hot Flashes in Men on Androgen Deprivation Therapy

To determine the efficacy of soy/isoflavone supplementation on hot flashes in men who are being treated with luteinizing hormone-releasing hormone (LHRH) agonist therapy for control of advanced prostate cancer

Literature has shown that low dose estrogens can control hot flashes in men on androgen deprivation but with a high risk of thromboembolic events. Soy derivatives that contain isoflavones, a type of phytoestrogen, have been evaluated in peri-menopausal women as a possible safer alternative to synthetic estrogens but there has not been a similar study performed on their effect in men on androgen deprivation therapy for prostate cancer.

Inclusion Criteria:

• Histologically proven adenocarcinoma of prostate with treatment of prostate cancer (radical prostatectomy, radiation therapy, etc.)
• had biochemical/clinical relapse and started on antiandrogens
• have documented history of hot flashes

Exclusion Criteria:

• History of MI, DVT, CVA
• peanut allergy
• untreated hypothyroidism
• must be off other medical treatment for hot flashes for 2 weeks before enrollment in this study