Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| HSREB 12845 |
Not provided
Not provided
Not provided
Unable to recruit enough patients to continue on with the study.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Ontario Neurotrauma Foundation | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
We hypothesize that probiotic Lactobacillus can augment antibiotic treatment of symptomatic urinary tract infection (UTI) in spinal cord injured patients, and also increase the time to the next episode of UTI.
Subjects will be recruited from the outpatient population and 'alumni' of the Regional SCI Rehabilitation Programs in London (Parkwood Hospital/St Joseph's Health Care) and Hamilton (Hamilton Health Sciences Centre) Ontario.
Community living paraplegic and tetraplegic men and women (18 years and above) who present to their family physician or specialist with symptomatic UTI will be prescribed an antibiotic treatment for up to 14 days (using the drug of choice i.e. which the treating physician deems appropriate) and randomized to also receive by mouth two capsules containing placebo or probiotic Lactobacillus rhamnosus GR-1 and L. reuteri RC-14 daily.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Probiotic Lactobacillus GR-1 and RC-14 | Other | Two capsules of Lactobacillus GR-1 and RC-14 daily for 12 months |
|
| Measure | Description | Time Frame |
|---|---|---|
| Increase time to next UTI | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Numbers of infections of any type occurring during probiotic treatment | 12 months |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Patrick J Potter, MD FRCPC | St. Joseph's Health Care Centre, Parkwood Hospital, Lawson Health Research Institute | Principal Investigator |
| Gregor Reid, PhD, MBA | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Study Director |
| Keith Hayes, PhD | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Study Chair |
| Kingsley C Anukam, PhD | Lawson Health Research Institute, kanukam@uwo.ca | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| St. Joseph's Health Care | London | Ontario | N6A 4V2 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17324320 | Background | Hayes KC, Bassett-Spiers K, Das R, Ethans KD, Kagan C, Kramer JL, Linsenmeyer T, Moore KN, Razvi H, Reid G, Walter JS, Wilson JW. Research priorities for urological care following spinal cord injury: recommendations of an expert panel. Can J Urol. 2007 Feb;14(1):3416-23. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D013119 | Spinal Cord Injuries |
| D014552 | Urinary Tract Infections |
| ID | Term |
|---|---|
| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020196 | Trauma, Nervous System |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| D014947 | Wounds and Injuries |
| D007239 | Infections |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |