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| ID | Type | Description | Link |
|---|---|---|---|
| 5R01DK066108 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | NIH |
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Lifestyle choices,including diet,are conducive to healthy body weights in children. Dairy products and calcium supplementation have been associated with moderation of body weight and body fat. This study was designed to test the following hypotheses with overweight and obese adolescents consuming a controlled diet:
Subjects will consume a controlled diet containing 800 mg calcium for two three week periods. During one period they will also receive a frozen ice cream like product (smoothie) twice a day based on soy protein that contains no additional calcium. During the other period they will receive a similar product twice a day based on either dairy protein that contains 650 mg calcium or based on soy protein that contains 650 mg calcium as calcium carbonate
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| C | Placebo Comparator | During one three week session of a controlled diet subjects will receive a smoothie based on soy protein two times per day that does not contain any additional calcium |
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| B | Active Comparator | During one three week period half of the participants will receive two smoothies per day based on soy protein that contain 650 mg Ca as calcium carbonate |
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| A | Active Comparator | During one three week session subjects will receive two smoothies per day based on dairy protein containing 650 mg calcium |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| C (smoothies based on soy protein containing no additional calcium) | Dietary Supplement | Two smoothies per day based on soy protein containing no additional calcium |
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| Measure | Description | Time Frame |
|---|---|---|
| Energy balance will be calculated by quantitating the kilocalories represented by the following components: dietary intake, excreta, physical activity, resting energy expenditure, thermic effect of food, and thermogenesis. | After equilibration on a controlled diet for one week, measurements will be taken over an additional two week period. |
| Measure | Description | Time Frame |
|---|---|---|
| Serum biochemical measures of calcium metabolism (PTH, Vitamin D, and calcium) | Serial meausures over a 10 hour period following a meal containing calcium from the placebo, dairy or calcium carbonate supplement | |
| Calcium retention | Two weeks on a controlled diet following one week of equilibration on the same diet |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Connie Weaver, PHD | Department Foods and Nutrition, Purdue University | Principal Investigator |
| Berdine R Martin, PhD | Department Foods and Nutrition, Purdue University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Foods and Nutrition | West Lafayette | Indiana | 47907 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21918216 | Derived | Weaver CM, Campbell WW, Teegarden D, Craig BA, Martin BR, Singh R, Braun MM, Apolzan JW, Hannon TS, Schoeller DA, DiMeglio LA, Hickey Y, Peacock M. Calcium, dairy products, and energy balance in overweight adolescents: a controlled trial. Am J Clin Nutr. 2011 Nov;94(5):1163-70. doi: 10.3945/ajcn.110.010264. Epub 2011 Sep 14. | |
| 19386746 | Derived | Singh R, Martin BR, Hickey Y, Teegarden D, Campbell WW, Craig BA, Schoeller DA, Kerr DA, Weaver CM. Comparison of self-reported, measured, metabolizable energy intake with total energy expenditure in overweight teens. Am J Clin Nutr. 2009 Jun;89(6):1744-50. doi: 10.3945/ajcn.2008.26752. Epub 2009 Apr 22. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| B (smoothies based on soy protein containing calcium) | Dietary Supplement | Two smoothies daily based on soy protein containing 650 mg calcium as calcium carbonate |
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| A (smoothies based on dairy protein containing calcium) | Dietary Supplement | Two smoothies daily based on dairy protein containing 650 mg calcium |
|
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |