Optimal Heparin Dosing Regimens for Cardiopulmonary Bypass

Optimal Heparin Dosing Regimens for Cardiopulmonary Bypass

Study has been completed and is in the data analysis and manuscript writing phase of the project.

Inclusion Criteria:

• Adult male and non-pregnant female patients scheduled for elective cardiac surgery requiring CPB will be eligible for enrollment.

Exclusion Criteria:

• Age less than 18 or greater than 90 years; emergency surgery
• Circulatory arrest
• Combined non-cardiac procedures such as carotid endarterectomy
• Congenital heart repair
• Off-CPB coronary artery bypass grafting (CABG)
• Clotting disorder
• Fibrinolytic agents (e.g. streptokinase), severe hepatic disease
• Aprotinin use
• Cooling < 28 degrees C during CPB
• Dialysis dependent renal failure; and
• Platelet receptor GP3a/2b antagonists medication received within 48 hours of surgery. Patients that are not receiving tranexamic acid (TA) intraoperatively will be excluded.