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Fractionated radiotherapy induces an observable change in the proliferative activity as assessed by pre-treatment and early-treatment 18F-FLT PET imaging. This study is designed to investigate 18F-FLT as a PET imaging agent for predicting treatment effectiveness in several tumors and will serve as a pilot study to a planned PO1 submission
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 2. Head and neck | Experimental | Imaging with 18F-FLT PET |
|
| 3. Lung | Experimental | Imaging with 18F-FLT PET |
|
| 4. prostate | Experimental | Imaging with 18F-FLT PET |
|
| 5. esophagus | Experimental | Imaging with 18F-FLT PET |
|
| 1.CNS | Experimental | Imaging with 18F-FLT PET |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Imaging with 18F-FLT PET | Procedure | Imaging with 18F-FLT PET |
| |
| Measure | Description | Time Frame |
|---|---|---|
| To test whether the cellular response to fractionated radiotherapy leads to observable global change in the uptake of 18F-FLT as assessed by PET imaging | end of study |
| Measure | Description | Time Frame |
|---|---|---|
| To assess the technical and logistic feasibility of 18F-FLT scans in a population of cancer patients | end of study |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Robert Jeraj, Ph.D. | University of Wisconsin, Madison | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Wisconsin Hospital and clinis | Madison | Wisconsin | 53792 | United States |
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| ID | Term |
|---|---|
| D006258 | Head and Neck Neoplasms |
| D008175 | Lung Neoplasms |
| D011471 | Prostatic Neoplasms |
| D004938 | Esophageal Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
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| ID | Term |
|---|---|
| D014965 | X-Rays |
| ID | Term |
|---|---|
| D060733 | Electromagnetic Radiation |
| D055590 | Electromagnetic Phenomena |
| D060328 | Magnetic Phenomena |
| D055585 | Physical Phenomena |
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| Imaging with 18F-FLT PET |
| Procedure |
Imaging with 18F-FLT PET |
|
| Imaging with 18F-FLT PET | Procedure | Imaging with 18F-FLT PET |
|
| Imaging with 18F-FLT PET | Procedure | Imaging with 18F-FLT PET |
|
| Imaging with 18F-FLT PET | Procedure | Imaging with 18F-FLT PET |
|
| D008171 |
| Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D005834 | Genital Neoplasms, Male |
| D014565 | Urogenital Neoplasms |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D011469 | Prostatic Diseases |
| D052801 | Male Urogenital Diseases |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D004066 | Digestive System Diseases |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
| D011827 | Radiation |
| D011839 | Radiation, Ionizing |