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The objective of this study is to determine if corneal topography can be used to predict the fluorescein pattern of keratoconus lenses on the eye. A corneal topography image will be taken and the computer selected lens will be placed on the eye. After placement of the lens color photographs will be taken of the eye's fluorescein pattern and compared to the computer predicted pattern.
Subject population: keratoconus patients who have not undergone corneal surgery 100 subjects who come to UIHC for their contact lens care. We will approach them at their visit. We will not call potential participants from a database.
If topography is impossible to capture. Concommitant Corneal Disease Minors will be excluded
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Corneal Topographer Fluorescein Patterns | Use corneal topography to evaluate fluorescein pattern of rgp contact lens. Used corneal topography to develop theoretical fluorescein patters on a virtual eye. Theoretical lens developed by the topographer was ordered to compare to the actual fluorescein pattern on the actual eye. |
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| Measure | Description | Time Frame |
|---|---|---|
| Number of Participants With an Observable Difference Between Virtual Versus Actual Fluorescein Patterns | Comparison of fluorescein patterns of rgp contact lens. Bearing and elevation fluorescein patterns will be compared between the actual (photo) and theoretical (computer generated) fluorescein patterns using standard clinical means. | Baseline first visit |
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Inclusion Criteria:
18 yrs of age or older with diagnosis of keratoconus and contact lens wearer
Exclusion Criteria:
Noncommittant corneal disease or surgery Inability to capture topography measurement
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18 yrs of age or older with diagnosis of keratoconus and contact lens wearer
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| Name | Affiliation | Role |
|---|---|---|
| Christine W. Sindt, OD | University of Iowa | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Iowa Hospitals and Clinics - Dept. of Ophthalmology | Iowa City | Iowa | 52242 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 9148262 | Background | Szczotka LB. Clinical evaluation of a topographically based contact lens fitting software. Optom Vis Sci. 1997 Jan;74(1):14-9. doi: 10.1097/00006324-199701000-00015. | |
| 10810939 | Background | Jani BR, Szczotka LB. Efficiency and accuracy of two computerized topography software systems for fitting rigid gas permeable contact lenses. CLAO J. 2000 Apr;26(2):91-6. |
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| ID | Title | Description |
|---|---|---|
| FG000 | Corneal Topographer Flourscein Patterns | Use corneal topography to evaluate fluorescein pattern of rgp contact lens Comparison of fluorescein patterns: Compare trial contact lens fitting to fitting contact lenses based on corneal topography measurement |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
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| ID | Title | Description |
|---|---|---|
| BG000 | Corneal Topographer Flourscein Patterns | Use corneal topography to evaluate fluorescein patter of rgp contact lens Comparison of fluorescein patterns: Compare trial contact lens fitting to fitting contact lenses based on corneal topography measurement |
| Units | Counts |
|---|---|
| Participants |
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| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Number of Participants With an Observable Difference Between Virtual Versus Actual Fluorescein Patterns | Comparison of fluorescein patterns of rgp contact lens. Bearing and elevation fluorescein patterns will be compared between the actual (photo) and theoretical (computer generated) fluorescein patterns using standard clinical means. | Posted | Number | participants | Baseline first visit |
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Corneal Topographer Flourscein Patterns | Use corneal topography to evaluate fluorescein pattern of rgp contact lens Comparison of fluorescein patterns: Compare trial lens contact lens fitting to fitting contact lenses based on corneal topography measurement |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. Christine W. Sindt | University of Iowa | 319-356-2916 | christine-sindt@uiowa.edu |
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| ID | Term |
|---|---|
| D007640 | Keratoconus |
| ID | Term |
|---|---|
| D003316 | Corneal Diseases |
| D005128 | Eye Diseases |
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| 2049828 | Background | Rabinowitz YS, Garbus JJ, Garbus C, McDonnell PJ. Contact lens selection for keratoconus using a computer-assisted videophotokeratoscope. CLAO J. 1991 Apr;17(2):88-93. |
| 14564765 | Background | Szczotka LB. Corneal topography and contact lenses. Ophthalmol Clin North Am. 2003 Sep;16(3):433-53. doi: 10.1016/s0896-1549(03)00054-3. |
| 9800058 | Background | Bufidis T, Konstas AG, Mamtziou E. The role of computerized corneal topography in rigid gas permeable contact lens fitting. CLAO J. 1998 Oct;24(4):206-9. |
| Participants |
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| Sex: Female, Male | Count of Participants | Participants |
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| 18 |
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| 18 |
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