A Randomized Study of Whether Alfuzosin(Xatral) Helps in the Passage of Kidney Stones

A Randomized, Double-Blinded Placebo-Controlled Trial of Alfuzosin (Xatral)in the Management of Distal Ureteral Calculi

Patients who present for the first time to Emergency Room with renal colic due to a distal ureteral calculus (as diagnosed with spiral CT scan and KUB) will be randomized to receive Xatral 10mg po once a day or placebo once discharged from the ER. The purpose of this study is to assess if patients treated with Xatral will have a higher spontaneous passage rate of their ureteral stone than those treated with placebo.

Inclusion Criteria:

• first presentation to ER with renal colic secondary to a distal ureteral stone diagnosed on spiral CT scan
• stone radiopaque on KUB, distal to the sacro-iliac joint
• patient suitable for discharge from ER
• patient willing to return for follow-up on a weekly basis for maximum 4 visits

Exclusion Criteria:

• more than one ureteral calculi
• radiolucent stones or cystine stones
• prior ipsilateral calculus or ureteral surgery
• congenital anomalies of the ureter
• patients presents with an absolute indication for intervention
• allergy or contraindication to NSAIDs (history of orthostatic hypotension, current systolic BP <90 mmHg)
• patient currently taking an alpha-blocker
• hepatic insufficiency
• pregnancy