NM404 as an Imaging Agent in Patients With NSCLC

NM404 as an Imaging Agent in Patients With Non-small Cell Lung Cancer (NSCLC)

This study seeks to determine imaging characteristics of radiolabelled 131-I-NM404 in ten patients with cancer, including calculations of PKs, radiation dosimetry, biodistribution, and optimal imaging times (part 1 - complete).

In addition, specific tumor accumulation and metabolic fate of 131-I-NM404 will be determined in NSCLC tumors collected in 5 patients (part 2 - complete). Lastly, the study will collect preliminary data on imaging NSCLC tumors in up to 12 patients with evaluable disease (part 3 - ongoing).

Inclusion Criteria: Part 3

• Histologically or cytologically documented NSCLC with measurable of disease
• Disease is evaluable by CT scan
• At least 18 years old. Women cannot be pregnant or breastfeeding
• Karnofsky score >/= to 60
• Adequate renal/hepatic function
• Adequate blood cell count levels

Exclusion Criteria:

• Concomitant infection
• Other active cancers