Sluggish enrollment

This medication is used for procedural sedation and sedation for diagnostic imaging. The purpose of this study is to find out what happens to pentobarbital in the body after it is given to children who have had heart surgery.

This clinical trial of pentobarbital admistered as a bolus dose for procedural or imaging seddation will determine the PK of the drug in neonates, infants,, and children who are postoperative from cardiac surgery. Pediatric patients hsopitalized in the CICU who would receive IV bolus doses of pentobarbital as standard of care are eligible.

Inclusion Criteria:

• Will receive intravenous pentobarbital for procedural/imaging sedation as standard of care
• Age(Neonates, Young Infants, Older Infants, and Children Up to 6 years old)
• Diagnosis either postop from cardiac surgery or requrie sedation with IV pentobarbital as standard of care
• Adequate liver function tests
• Informed consent

Exclusion Criteria:

• Pregnant or lactating females
• Parents/guardians or subjects who, in the opinion of the Investigator, may be non-compliant with study schedules or procedures.

All patients enrolled in this study will be postoperative from cardiac surgery adn have require sedation for a procedure or diagnostic imaging.