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The purpose of this study is to determine the safe and effective levels of optical stimulation in peripheral nerves of humans otherwise undergoing nerve lesioning in surgery.
The purpose of this study is to determine the safe and effective levels of optical stimulation in peripheral nerves of humans otherwise undergoing nerve lesioning in surgery, namely children undergoing selective rhizotomy for treatment of medically refractory spasticity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Rhizotomy for children with spasticity | Children with spasticity needing Rhizotomy surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rhizotomy for children with spasticity | Procedure | Optical Stimulation versus electrical stimulation in children who need Rhizotomy Surgery for spasticity |
|
| Measure | Description | Time Frame |
|---|---|---|
| A brief series of optical versus electrical stimulation of the nerve will be used to measure the efficacy of optical stimulation | 4 hours |
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Inclusion Criteria:
Exclusion Criteria:
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Children over the age of 3 and younger than 17 years who have failed appropriate medical therapy for spasticity and are recommended for Rhizotomy surgery
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| Name | Affiliation | Role |
|---|---|---|
| Peter E Konrad, MD, Ph.D. | Vanderbilt University, Dept. Neurosurgery | Study Chair |
| Chanqing Kao, MD, Ph.D. | Vanderbilt University, Dept. Neurosurgery | Principal Investigator |
| Michael Remple, Ph.D. | Vanderbilt University, Dept. Neurosurgery | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Vanderbilt University | Nashville | Tennessee | 37232 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26157986 | Result | Cayce JM, Wells JD, Malphrus JD, Kao C, Thomsen S, Tulipan NB, Konrad PE, Jansen ED, Mahadevan-Jansen A. Infrared neural stimulation of human spinal nerve roots in vivo. Neurophotonics. 2015 Jan;2(1):015007. doi: 10.1117/1.NPh.2.1.015007. Epub 2015 Feb 23. |
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| ID | Term |
|---|---|
| D009128 | Muscle Spasticity |
| ID | Term |
|---|---|
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D009122 | Muscle Hypertonia |
| D020879 | Neuromuscular Manifestations |
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| ID | Term |
|---|---|
| D019051 | Rhizotomy |
| ID | Term |
|---|---|
| D003714 | Denervation |
| D019635 | Neurosurgical Procedures |
| D013514 | Surgical Procedures, Operative |
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abnormal spinal nerves that have been surgically removed
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |