Study of Optimal Posology of Gonadotrophins in Patients With Insufficient Ovarian Response Due to Age

Study of Optimal Posology of Gonadotrophins in Patients With Insufficient Ovarian Response Due to Age

In In vitro fertilization (IVF) treatment, poor responder patients of more than 38 years old are randomized prospectively into two dosages of gonadotrophins. The outcome of treatment will be analyzed.

Women > 38 years, who had an insufficient response to stimulation with regular (for age) posology of 225 IU of gonadotrophins (urinary or recombinant), in an agonist protocol will be randomized prospectively into 2 groups:

300 IU versus 450 IU of Gonal-f® administered in a short agonist protocol. Insufficient response is defined as: development of ≤ 4 mature follicles (of ≥ 16 mm) at time of hCG administration.

Patient can be eligible for several cycles in same protocol.

Inclusion Criteria:

• Women > 38 years with insufficient response to stimulation with 225 IU of gonadotrophins (urinary or recombinant), in an agonist protocol.
• Insufficient response is defined as: development of ≤ 4 mature follicles (of ≥ 16 mm) at time of hCG administration.
• Patient can be eligible for several cycles in same protocol.

Exclusion Criteria:

• Patients who already received doses > 225 IU
• Patients older than 42 years
• Patients with basal FSH concentrations ≥ 15 mU/ml at day 3