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no funding
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The purpose of this study is to evaluate the effects of ranolazine, an FDA-approved medication for the treatment of angina, on heart function by using echocardiography.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Other | Active drug for 2 weeks, then washout period for 2 weeks, then placebo for 2 weeks |
|
| 2 | Other | Placebo for 2 weeks, then washout for 2 weeks, then ranolazine for 2 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ranolazine | Drug | extended release 500 mg twice a day for two weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in E/Ea | 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| changes in mitral inflow parameters (E, A, IVRT, DT) | 2 weeks | |
| Changes in tissue doppler parameters (Ea, Aa) | 2 weeks | |
| Changes in pulmonary venous inflow (S, D, a reversal) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anthony DeMaria, MD | UCSD Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UCSD Medical Center | San Diego | California | 92103 | United States |
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| ID | Term |
|---|---|
| D054144 | Heart Failure, Diastolic |
| ID | Term |
|---|---|
| D006333 | Heart Failure |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D000069458 | Ranolazine |
| ID | Term |
|---|---|
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 |
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| 2 weeks |
| Aniline Compounds |
| D000588 | Amines |
| D010879 | Piperazines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |