Study of Varencline Effects on Cigarette Smoking Reward and Craving During a Model of Brief Quit Attempt

Placebo-controlled Study of Varenicline Effects on Nicotine Withdrawal Followed by a Test of Smoking Topography, Reward, and Reinforcement

Study of varenicline 2.0 mg/day treatment for 2 weeks with smoking test done in laboratory on Day 8 and a 1 week quit attempt from Day 8-14.

Inclusion Criteria:

• At least 10 cigarettes/day
• Interest in quitting smoking
• Willgness to comply with overnight smoking abbstiennce period followed by lab smoking test

Exclusion Criteria:

• Pregnancy
• Axis I psychiatric disorder which require treatment with psychoactive medication and would make study compliance difficult.
• Clinically significant medical condition in opinion of study clinician
• Drug or alcohol dependence inlast 12 months
• Use of other smoking cessation medications ot treatment progams in last 2 months