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2000 international units (IU) vitamin D, 1 gram (gm) calcium, or both given to children with Juvenile Rheumatoid Arthritis (JRA) may increase percent true calcium absorption, bone mineral turnover and/or bone mineralization.
Supplementation With 2000 IU Vitamin D, 1 gm Calcium or Both on Calcium Absorption and Bone Mineralization in Children With Juvenile Rheumatoid Arthritis may increase percent true calcium absorption, bone mineral turnover and/or bone mineralization.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Experimental | order of interventions placebo,calcium, cholecalciferol, calcium plus cholecalciferol |
|
| Calcium | Experimental | order of treatment calcium, placebo, calcium plus cholecalciferol, cholecalciferol |
|
| Cholecalciferol | Experimental | order of treatments cholecalciferol, calcium and Cholecalciferol, placebo, and calcium |
|
| Calcium and cholecalciferol | Experimental | order of treatment calcium and cholecalciferol, cholecalciferol, calcium, placebo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cholecalciferol | Dietary Supplement | 2000IU Cholecalciferol P.O. Q.D. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Percent true calcium absorption | After 6 months of treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Bone Mineralization by Dual Energy x-ray absorption | After 6 months treatment plus 3 month washout |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Laura S Hillman, MD | University of Missouri-Columbia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Missouri Hospitals and clinics | Columbia | Missouri | 65203 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18821668 | Derived | Hillman LS, Cassidy JT, Chanetsa F, Hewett JE, Higgins BJ, Robertson JD. Percent true calcium absorption, mineral metabolism, and bone mass in children with arthritis: effect of supplementation with vitamin D3 and calcium. Arthritis Rheum. 2008 Oct;58(10):3255-63. doi: 10.1002/art.23809. |
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| Calcium | Dietary Supplement | 1 gm calcium as calcium carbonate |
|
| Calcium and cholecalciferol | Dietary Supplement | 2000IU cholecalciferol and 1 gm calcium P.O. Q.D. for 6 months |
|
| Placebo | Drug | Placebo |
|
| ID | Term |
|---|---|
| D001171 | Arthritis, Juvenile |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
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| ID | Term |
|---|---|
| D002762 | Cholecalciferol |
| D002118 | Calcium |
| ID | Term |
|---|---|
| D002782 | Cholestenes |
| D002776 | Cholestanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013261 | Sterols |
| D014807 | Vitamin D |
| D012632 | Secosteroids |
| D008563 | Membrane Lipids |
| D008055 | Lipids |
| D008673 | Metals, Alkaline Earth |
| D004602 | Elements |
| D007287 | Inorganic Chemicals |
| D008670 | Metals |
| D001779 | Blood Coagulation Factors |
| D001685 | Biological Factors |
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