Trial of Folic Acid Effect on Hcy and cIMT After Kidney Tx

Clinical Trial of Effectiveness of Folic Acid Therapy on Homocysteine Level and Carotid Intima-Media Thickness After Kidney Transplantation

To see the effect of Folic acid supplementation after kidney transplantation on plasma total homocysteine level and carotid intimal-media thickness

Inclusion Criteria:

• having hyperhomocysteinemia(tHcy>12.5 µmol/L in men and 11.5 µmol/L in women )
• No evident history of CVD 4. no evidence of cigarette smoking
• not participating in other clinical studies on evaluation of cardiac diseases and
• not taking any lipid lowering treatment
• not being pregnant or breast feeding a baby(women)
• Having HIV or viral hepatitis infections.

Exclusion Criteria:

• unstable condition of the transplanted kidney (Cr> 3 mg/dl, BUN > 50 mg/dl)
• Cyclosporine (CsA) intoxication
• New onset of any severe disease ( such as MI, stroke, DM, etc.).