No longer viable

Study to determine drug interactions between GW273225 and the anticonvulsants valproate, carbamazepine or phenytoin

Inclusion criteria:

• Confident diagnosis of epilepsy
• Currently on VPA, CBZ or PHT
• >or= 4 seizures/4 weeks prior to screen

Exclusion criteria:

• Prior lamotrigine use (excluded if treatment discontinued for clinically significant safety reasons (i.e., rash, hypersensitivity)).
• Females of childbearing potential on hormonal contraceptives or hormone replacement therapy.