A Long-Term, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Radiographic Study To Investigate The Safety And Efficacy Of Orally Administered SD-6010 In Subjects With Symptomatic Osteoarthritis Of The Knee
A Long-Term, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Radiographic Study To Investigate The Safety And Efficacy Of Orally Administered SD-6010 In Subjects With Symptomatic Osteoarthritis Of The Knee
The objective of this 2-year study is to evaluate the safety, tolerability and disease modifying efficacy of SD 6010, an inhibitor of inducible nitric oxide synthase (iNOS), in overweight and obese subjects with knee osteoarthritis. The efficacy of SD-6010 will be evaluated by radiography using joint space narrowing in the medial tibiofemoral compartment of the study knee as the primary endpoint.
Inclusion Criteria:
Exclusion Criteria:
Gainesville, Florida 32607, United States
West Palm Beach, Florida 33407, United States
Cadillac, Michigan 49601, United States
Syracuse, New York 13210, United States
Praha 11 - Chodov, 148 00, Czechia
Praha 11 - Chodov, 148 00, Czechia
Arenzano, 16011, Italy
Milan, 20157, Italy
Santiago de Surco, Lima region Lima 33, Peru
Callao, Provincia Constitucional del Callao Callao-02, Peru
Saint Petersburg, 194291, Russia
Saint Petersburg, 195427, Russia