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| ID | Type | Description | Link |
|---|---|---|---|
| ZonMW 1135.0010 |
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| Name | Class |
|---|---|
| ZonMw: The Netherlands Organisation for Health Research and Development | OTHER |
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Palliative care in cancer aims at alleviating the suffering of patients. A previous study in patients with advanced non-small-cell lung cancer showed that adenosine 5'-triphosphate (ATP) infusions had a favourable effect on fatigue, appetite, body weight, muscle strength, functional status, quality of life, and survival. Based on these promising results, the present study was designed 1. To evaluate whether the beneficial effects of ATP administration observed in patients with advanced lung cancer would also be present in pre-terminal cancer patients of different tumour types, and 2. To test the feasibility of application of ATP infusions in a home care setting.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| I | Experimental |
| |
| C | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Adenosine 5'-triphosphate | Drug | Weekly ATP infusions (in total 8 infusions) during 8 - 12 hours in a maximum dose of 50 mcg/kg.min |
|
| Measure | Description | Time Frame |
|---|---|---|
| Survival Physical restriction Fatigue Quality of life | 0-8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Appetite Nutritional intake Body height Body weight Triceps skin fold thickness Mid-upper arm circumference Strength of elbow flexor and knee extensor muscles Handgrip strength Process evaluation | 0-8 weeks |
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Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| P.C. Dagnelie, PhD | Maastricht University - Department of Epidemiology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maxima Medical Center | Eindhoven | 5600 PD | Netherlands | |||
| Catharina Hospital Eindhoven |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 10675381 | Background | Agteresch HJ, Dagnelie PC, van der Gaast A, Stijnen T, Wilson JH. Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst. 2000 Feb 16;92(4):321-8. doi: 10.1093/jnci/92.4.321. | |
| 11786563 | Background | Agteresch HJ, Rietveld T, Kerkhofs LG, van den Berg JW, Wilson JH, Dagnelie PC. Beneficial effects of adenosine triphosphate on nutritional status in advanced lung cancer patients: a randomized clinical trial. J Clin Oncol. 2002 Jan 15;20(2):371-8. doi: 10.1200/JCO.2002.20.2.371. |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D000255 | Adenosine Triphosphate |
| ID | Term |
|---|---|
| D000227 | Adenine Nucleotides |
| D011685 | Purine Nucleotides |
| D011687 | Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
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| Eindhoven |
| 5602 ZA |
| Netherlands |
| Atrium MC | Heerlen | 6419 PC | Netherlands |
| Maastricht University Hospital | Maastricht | 6202 AZ | Netherlands |
| University Medical Center Utrecht | Utrecht | 3508 GA | Netherlands |
| 14501386 | Background | Agteresch HJ, Burgers SA, van der Gaast A, Wilson JH, Dagnelie PC. Randomized clinical trial of adenosine 5'-triphosphate on tumor growth and survival in advanced lung cancer patients. Anticancer Drugs. 2003 Sep;14(8):639-44. doi: 10.1097/00001813-200309000-00009. |
| D000072471 |
| Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D009711 | Nucleotides |
| D009706 | Nucleic Acids, Nucleotides, and Nucleosides |
| D012265 | Ribonucleotides |