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| ID | Type | Description | Link |
|---|---|---|---|
| HARECCTR0500036 |
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| Name | Class |
|---|---|
| Hoffmann-La Roche | INDUSTRY |
There is a significant (50-80%) risk of acute graft-versus-host disease(GVHD) and early mortality (30%) associated with high risk stem cell transplantation (SCT) such as that from a matched unrelated donor or HLA-mismatch sibling. Mycophenolate mofetil (MMF) has been shown to be an effective and safe immunosuppressant in the prevention and treatment of rejection after solid organ transplantation. Its role in acute GVHD prophylaxis in high risk SCT will be investigated in this clinical trial.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| mycophenolate mofetil, methotrexate, cyclosporin | Drug | |||
| Methotrexate and cyclosporin | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| acute GVHD incidence and grading | 100 Days | |
| chronic GVHD incidence | 3 Years |
| Measure | Description | Time Frame |
|---|---|---|
| Mortality, GVHD-related and all cause | 3 Years | |
| Symptomatic side effects attributed to MMF | 60 Days | |
| Date of engraftment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Winnie WW Cheung, Dr | Contact | (852) 2855 3111 | cheungww@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Lawrence SY Ma, Dr | Department of Medicine/ Haematology and Oncology, Queen Mary Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Queen Mary Hospital | Recruiting | Hong Kong | China |
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| Date of engraftment |
| ID | Term |
|---|---|
| D006086 | Graft vs Host Disease |
| ID | Term |
|---|---|
| D007154 | Immune System Diseases |
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| ID | Term |
|---|---|
| D009173 | Mycophenolic Acid |
| D008727 | Methotrexate |
| D016572 | Cyclosporine |
| ID | Term |
|---|---|
| D002208 | Caproates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
| D005227 | Fatty Acids |
| D008055 | Lipids |
| D000630 | Aminopterin |
| D011622 | Pterins |
| D011621 | Pteridines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D003524 | Cyclosporins |
| D010456 | Peptides, Cyclic |
| D047028 | Macrocyclic Compounds |
| D011083 | Polycyclic Compounds |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
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