Evaluation of Safety and Effects of SLx-4090 After Dosing for 14 Days in Subjects With High Triglycerides

A Randomised, Double-blind, Placebo Controlled Study to Evaluate the Pharmacodynamics, Safety, Tolerability and Pharmacokinetics Profile of SLx-4090 Over 14 Days Dosing in Subjects With High Triglyceride Values

The purpose is to investigate the effect of oral doses of SLx-4090 over 14 days on subjects with high triglycerides.

1. Serum triglycerides
2. Serum lipids and lipoproteins
3. Safety and tolerability

Inclusion Criteria:

• Male or female subjects with high triglyceride levels
• Male or female subjects between age 18 and 65 years, inclusive

Exclusion Criteria:

• History of drug abuse
• Any prescribed or over the counter medication taken within 2 weeks prior to administration of study drug or within 6 times the elimination half-life
• Blood donation of more than 500ml blood in the previous 3 months
• Any confirmed significant allergic reaction against any drug or multiple allergies