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Tuberculosis (TB) remains as an important public health problem worldwide. Pleural tuberculosis is the most prevalent form of extrapulmonary presentation in immunocompetent patients.
The volume of effusion in the pleural space of patients with pleural TB may cause complications like restrictive ventilator lung functional disturb and/or pleural thickening. The respiratory physiotherapy can be adjuvant on treatment of pleural effusion tuberculosis throughout of various treatment technique.
The Continuous positive airway pressure (CPAP) is utilized in various pathologic, this improves lung mechanics by recruiting atelectatic alveoli, improving pulmonary compliance, and reducing the work of breathing.
The aim of this study is to determine the effect of CPAP on fluid absorption among patients with pleural effusion due tuberculosis.
This randomized and controlled trial compared the reduction of the pleural effusion volume of the group of patients using the anti-TB standard regimen to that using the anti-TB standard regimen AND adjuvant treatment of physical therapy during four weeks.
Evaluation of the pleural effusion size: a helicoidal thoracic computed tomography (CT) was carried out in all patients enrolled. The valuation was conducted by two radiologists blinded for the treatment used, specifically trained for the purpose of the study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CPAP | Behavioral | Frequency of three times a week, using a positive end expiratory pressure (PEEP) of 10 mmH2O for 30 minutes for four weeks. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate of pleural effusion volume | one month |
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Inclusion Criteria:
Exclusion criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Juliana F Oliveira, MD | Universidade Federal do Rio de Janeiro | Principal Investigator |
| Marcus B. Conde, PhD | Universidade Federal do Rio de Janeiro | Principal Investigator |
| Rosana S. Rodrigues, MD | Universidade Federal do Rio de Janeiro | Study Chair |
| Sara L. Menezes, PhD | Universidade Federal do Rio de Janeiro | Principal Investigator |
| Ana L. Boechat, MD | Universidade Federal do Rio de Janeiro | Study Chair |
| Fernanda C. Mello, PhD | Universidade Federal do Rio de Janeiro | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clementino Fraga Filho University Hospital- Federal University of Rio de Janeiro | Rio de Janeiro | Rio de Janeiro | 21941913 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 9778201 | Background | Valdes L, Alvarez D, San Jose E, Penela P, Valle JM, Garcia-Pazos JM, Suarez J, Pose A. Tuberculous pleurisy: a study of 254 patients. Arch Intern Med. 1998 Oct 12;158(18):2017-21. doi: 10.1001/archinte.158.18.2017. | |
| 17492379 | Background | Masip J. Non-invasive ventilation. Heart Fail Rev. 2007 Jun;12(2):119-24. doi: 10.1007/s10741-007-9012-7. |
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| ID | Term |
|---|---|
| D014376 | Tuberculosis |
| D010996 | Pleural Effusion |
| ID | Term |
|---|---|
| D009164 | Mycobacterium Infections |
| D000193 | Actinomycetales Infections |
| D016908 | Gram-Positive Bacterial Infections |
| D001424 | Bacterial Infections |
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| 17273621 | Background | Seiscento M, Conde MB, Dalcolmo MM. [Tuberculous pleural effusions]. J Bras Pneumol. 2006;32 Suppl 4:S174-81. doi: 10.1590/s1806-37132006000900003. Portuguese. |
| 12598215 | Background | Conde MB, Loivos AC, Rezende VM, Soares SL, Mello FC, Reingold AL, Daley CL, Kritski AL. Yield of sputum induction in the diagnosis of pleural tuberculosis. Am J Respir Crit Care Med. 2003 Mar 1;167(5):723-5. doi: 10.1164/rccm.2111019. |
| 7301718 | Result | Vandevenne A, Moyses B, Weitzenblum E, Carloz I, Methlin G. [Regional pulmonary function in unilateral sero-fibrinous pleural effusions and changes under the influence of treatment (author's transl)]. Poumon Coeur. 1981;37(3):223-8. French. |
| 9150338 | Result | Ferrer J. Pleural tuberculosis. Eur Respir J. 1997 Apr;10(4):942-7. |
| 12603352 | Result | Zhou A, Guo L, Tang L. Effect of an intrathoracic injection of sodium hyaluronic acid on the prevention of pleural thickening in excess fluid of tuberculous thoracic cavity. Clin Exp Pharmacol Physiol. 2003 Mar;30(3):203-5. doi: 10.1046/j.1440-1681.2003.03804.x. |
| 20464170 | Derived | Oliveira JF, Mello FC, Rodrigues RS, Boechat AL, Conde MB, Menezes SL. Effect of continuous positive airway pressure on fluid absorption among patients with pleural effusion due to tuberculosis. Rev Bras Fisioter. 2010 Mar-Apr;14(2):127-32. doi: 10.1590/s1413-35552010005000001. Epub 2010 Apr 30. |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
| D010995 | Pleural Diseases |
| D012140 | Respiratory Tract Diseases |