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| Name | Class |
|---|---|
| Merck Sharp & Dohme LLC | INDUSTRY |
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The purpose of the study is to find out if montelukast can be used to treat the various symptoms of allergic syndrome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | 3 weeks of Montelukast and 3 weeks of placebo treatment |
|
| 2 | Active Comparator | 3 weeks of placebo and 3 weeks of montelukast treatment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| montelukast | Drug | 10 mg montelukast tablet each evening for 3 weeks or placebo for 3 weeks in cross-over manner |
|
| Measure | Description | Time Frame |
|---|---|---|
| Allergic symptoms | 3 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Need for antihistamines or inhaled beta-2-agonists to relieve symptoms | 3 weeks | |
| Exhaled nitric oxide concentration | 3 weeks |
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Inclusion Criteria:
Wheal diameter at least 4 mm in skin-prick test for both birch and timothy
Allergic symptoms in both upper airways (allergic rhinitis) and lower airways (asthma-like symptoms or diagnosed asthma) and at least one of the following:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Tari Haahtela, Professor | Skin and Allergy Hospital, Helsinki University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Skin and Allergy Hospital, Helsinki University Hospital | Helsinki | 00029 HUS | Finland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19127072 | Derived | Lehtimaki L, Petays T, Haahtela T. Montelukast is not effective in controlling allergic symptoms outside the airways: a randomised double-blind placebo-controlled crossover study. Int Arch Allergy Immunol. 2009;149(2):150-3. doi: 10.1159/000189198. Epub 2009 Jan 6. |
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| ID | Term |
|---|---|
| D006255 | Rhinitis, Allergic, Seasonal |
| D003233 | Conjunctivitis, Allergic |
| D003876 | Dermatitis, Atopic |
| D001249 | Asthma |
| ID | Term |
|---|---|
| D065631 | Rhinitis, Allergic |
| D012220 | Rhinitis |
| D009668 | Nose Diseases |
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| C093875 | montelukast |
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| D012130 |
| Respiratory Hypersensitivity |
| D010038 | Otorhinolaryngologic Diseases |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D003231 | Conjunctivitis |
| D003229 | Conjunctival Diseases |
| D005128 | Eye Diseases |
| D012873 | Skin Diseases, Genetic |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D003872 | Dermatitis |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D017443 | Skin Diseases, Eczematous |
| D001982 | Bronchial Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |