Coronary MDCTA With Iopamidol Injection 370

A Phase II Multicenter Randomized Double Blind Dose Finding Study of Iopamidol Injection 370 in Multidetector Computed Tomographic Angiography (MDCTA) in Patients With Suspected Coronary Artery Stenosis

Determine the validity and compare the visualization of arterial segments obtained with 3 doses of iopamidol to determine dose for further investigation in future trials.

Inclusion Criteria:

• Provide informed consent
• At least 30 years of age
• Weight less than 250 lbs
• Known or suspected coronary artery disease and suspected to have significant coronary artery stenosis
• Undergo MDCTA scan
• Undergo coronary angiography within 2 weeks of MDCTA scan

Exclusion Criteria:

• Hx of hypersensitivity to iodinated contrast agents
• Known or suspected hyperthyroidism or pheochromocytoma
• Renal impairment
• History of coronary artery stent placement or bypass grafts
• Unstable
• Pregnant or lactating