Proteomics Analysis for Recognition of Acute Cellular Rejection After Lung Transplantation

Proteomics Analysis for Recognition of Acute Cellular Rejection After Lung Transplantation

In patients with acute rejection after lung transplantation the peptide profile in broncho-alveolar lavage (BAL) and urine should be compared in order to identify a paradigm that allows an non-invasive rejection therapy.

Goal of the study is the establishment of biomarkers for early diagnosis of acute rejection, followed by a late validation of the paradigm with prospectively collected samples, which will be examined blinded.

Inclusion Criteria:

• Patients with stable graft function
• Patients with acute rejection

Exclusion Criteria:

• Acute infection
• BOS