Ulcer Prevention Study in Post Gastric Bypass Patients

A Randomized, Double-blind Clinical Trial Comparing Zegerid Capsule to Famotidine in Preventing Anastomotic (Marginal) Ulcers in Post Gastric Bypass Patients

This research is to determine which medication, Zegerid (Omeprazole/Sodium Bicarbonate) or Pepcid AC (Famotidine), works best at reducing the chance that a patient will get an ulcer after gastric bypass surgery.

The purpose of this research is to evaluate information about the control of gastric acid in post gastric bypass surgery patients. Goal is to determine which medication best reduces the incidence of anastomotic ulcers post-operatively.

Inclusion Criteria:

• Subject is age ≥ 18 years
• Patient meets the criteria for laparoscopic gastric bypass surgery
• Females only: Patient is willing to take a urine pregnancy test

Exclusion Criteria:

• Subject allergic to omeprazole or famotidine
• Patient receiving antifungal (i.e. ketoconazole or itraconazole)
• Hepatic insufficiency
• History of Crohns disease
• History of Zollinger-Ellison disease
• Patient received an investigational drug within 30 days of enrollment
• Patient currently enrolled in another research project
• Females Only: Pregnancy or plan on becoming pregnant during the next 14 weeks