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The purpose of this study is to see whether injecting local anaesthetic into the vaginal tissues,just prior to transvaginal egg collection,will decrease the amount of pain experienced by women having their eggs collected on an IVF cycle. All women will also receive intravenous sedation as required as well as a sleeping tablet thirty minutes prior to the procedure which is our routine procedure for egg collection.
Transvaginal oocyte retrieval is the most common method of oocyte collection in IVF cycles. A variety of different methods are used to provide analgesia/anesthesia for oocyte collection. Our unit has always used an oral pre-medication followed by intravenous fentanyl during the procedure but this doesn't seem to provide adequate analgesia for some women. The aim of this study was to compare the addition of intravaginal local anaesthetic injection versus saline placebo to our usual analgesia regime to see whether less intravenous fentanyl was required and whether the women experienced less pain during oocyte collection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| LA | Active Comparator | Intravaginal and pre-peritoneal injection of 1% lignocaine into each side of the upper vagina under ultrasound guidance immediately prior to ultrasound guided transvaginal oocyte retrieval |
|
| P | Placebo Comparator | Intravaginal saline placebo injection into each side of upper vagina under ultrasound guidance immediately prior to transvaginal oocyte retrieval |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| lignocaine | Drug | 20 mls of 1% lignocaine solution for injection, 10mls into each side of upper vagina, under ultrasound guidance immediately prior to transvaginal oocyte retrieval under ultrasound guidance from each ovary |
| Measure | Description | Time Frame |
|---|---|---|
| Total dose of iv fentanyl used during oocyte collection | Length of oocyte collection (minutes) |
| Measure | Description | Time Frame |
|---|---|---|
| Pain score (cm on a Visual Analogue Scale) at 6 different points during oocyte collection | Actual point in time | |
| Length of oocyte collection procedure | Time taken (minutes) | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sarah A Wakeman, FRANZCOG | The Fertility Centre | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Fertility Centre | Christchurch | Canterbury | 8014 | New Zealand |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D008012 | Lidocaine |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 |
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| normal saline | Drug | 20mls of normal saline solution, 10mls injected each side into upper vagina under ultrasound guidance, immediately prior to ultrasound guided transvaginal oocyte retrieval from each ovary |
|
| Occurence of nausea or vomiting |
| During oocyte collection procedure |
| Administration of atropine or anti -emetic | During oocyte collection procedure |
| Time spent in recovery room | Time from end of oocyte collection until discharge home |
| No of oocytes collected | During oocyte collection procedure |
| Number of oocytes fertilised | Assessed 18 hours after oocyte collection |
| Pregnancy outcome | 7 weeks gestation |
| Number of embryos frozen | Within 6 days of oocyte collection |
| Pulse rate at beginning and end of egg collection | Point in time |
| Maximum pulse rate during oocyte collection | Point in time during oocyte collection procedure |
| Aniline Compounds |
| D000588 | Amines |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |