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The purpose of this study is to determine the optimal dosage of the clinical trial which is evaluating the antihypertensive efficacy and the safety of OJP-2028 tablets in patients with the uncomplicated essential hypertension.
Evaluating the antihypertensive efficacy and the safety of OJP-2028 tablets in patients with the uncomplicated essential hypertension.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | Experimental | OJP-2028 1mg/day |
|
| Group 2 | Experimental | OJP-2028 2mg/day |
|
| Group 3 | Experimental | OJP-2028 4mg/day |
|
| Group 4 | Placebo Comparator | Placebo |
|
| Group 5 | Other | Reference drug |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| OJP-2028 | Drug | Experimental: 1mg/day, 2mg/day, 4mg/day for 8 weeks. Placebo Comparator: Placebo.day for 8 weeks. Reference group(Group 5): Reference Drug/day for 8 weeks. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Average SiDBP Differences of test group vs control group per each dosage by comparison with the baseline. | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Average SiSBP Differences of each group by comparison with the baseline. | 8 weeks | |
| Responder rate of each group by comparison with the baseline. | 8 weeks | |
| Average SiDBP and SiSBP Differences of each group by comparison with the baseline. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| CHEOL HO KIM | Seoul National University Bundang Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang Hospital | Seongnam-si, Gyeonggi-do | South Korea |
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| ID | Term |
|---|---|
| D000075222 | Essential Hypertension |
| ID | Term |
|---|---|
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| 8 weeks |