Evaluate the Effects of the Drug (SB-656933-AAA) on the Body After a Single Dose in Subjects Who Have Inhaled Ozone

A Dose Ranging Study to Assess the Effect of Pre-treatment With a Single Dose of Oral SB656933 on Lung Inflammation Following Challenge With Inhaled Ozone and Intermittent Exercise in Healthy Volunteers, Relative to Placebo

A study to evaluate the effect of SB-656933-AAA on the body after a single dose in subjects who have been challenged with ozone.

Inclusion Criteria:

• Healthy subjects between 18-50 years.
• Females should be of non-child bearing potential.
• Non-smoking for at least 12 months.
• Normal lung function.
• Subjects should be able to produce acceptable sputum samples.

Exclusion Criteria:

• Any serious medical condition.
• Hepatitis B or C and/or HIV positive.
• Currently on regular medication except paracetamol.
• Body Mass Index <20 or >30.