A Study for Type 2 Diabetic Patients

Comparison of Insulin Lispro Low Mixture With Insulin Glargine When Initiating and Intensifying Insulin Therapy As Required in Patients With Type 2 Diabetes Who Have Inadequate Glycemic Control on Oral Antihyperglycemic Medication

The purpose of the study is to compare the insulin lispro low mixture (1, 2 or 3 daily injections) with insulin glargine (alone or with 1, 2 or 3 insulin lispro daily injections) on lowering the blood sugar level

Inclusion Criteria:

• Type 2 diabetes mellitus
• Receiving oral antihyperglycemic medications (including metformin) without insulin injection in the last 90 days
• Hemoglobin A1c (HbA1c) equal to or greater than 7.0% but less than 11.0%
• Willing to receive insulin injection while continuing to take the prestudy oral antihyperglycemic medications
• Able to perform self monitoring of blood glucose

Exclusion Criteria:

• Are taking any other glucose-lowering agents other than metformin, sulfonylurea or Thiazolidinedione (Pioglitazone)
• Have taken acarbose, miglitol, pramlintide, exenatide, repaglinide, or nateglinide in the past 6 weeks, or for a total of 30 days or more, in the last 24 weeks
• Have a body mass index greater than 35 kg/m2
• History or presence of kidney disease
• Have cardiac disease (Class III or IV)