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| ID | Type | Description | Link |
|---|---|---|---|
| MK0507A-153 | |||
| 2007_027 |
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Evaluate the effectiveness of dorzolamide-timolol (Cosopt®) as first line therapy in reducing intraocular pressure in patients with untreated Open angle glaucoma (OAG) or Ocular hypertension (OH).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | dorzolamide HCl/timolol maleate |
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| 2 | Experimental | dorzolamide hydrochloride/timolol maleate + prostaglandin |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| dorzolamide hydrochloride (+) timolol maleate | Drug | Combination treatment of dorzolamide HCl (2%)/ timolol maleate (0.5%) BID for six weeks in patients with open-angle glaucoma or ocular hypertension. For patients who achieve target IOP at 6 weeks, dorzolamide/timolol is continued for another 6 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Reduction in IOP 4 mmHg (or >= 20%) over a period of 6 or 12 weeks. | 6 to 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Medical Monitor | Merck Sharp & Dohme LLC | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20874498 | Result | Crichton AC, Harasymowycz P, Hutnik CM, Behki R, Boucher S, Ibrahim F, Rifkind AW, Solomon L, Liao C, Bastien NR, Sampalis JS. Effectiveness of dorzolamide-timolol (COSOPT) in patients who were treatment naive for open-angle glaucoma or ocular hypertension: the COSOPT first-line study. J Ocul Pharmacol Ther. 2010 Oct;26(5):503-11. doi: 10.1089/jop.2010.0032. |
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| ID | Type | URL | Comment |
|---|---|---|---|
| CSR Synopsis | View IPD |
| ID | Term |
|---|---|
| D005901 | Glaucoma |
| D009798 | Ocular Hypertension |
| ID | Term |
|---|---|
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| C479140 | dorzolamide-timolol combination |
| D011453 | Prostaglandins |
| ID | Term |
|---|---|
| D015777 | Eicosanoids |
| D005231 | Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D008055 | Lipids |
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| Comparator: dorzolamide HCl/timolol maleate + prostaglandin | Drug | Combination treatment of dorzolamide HCl (2%)/timolol maleate(0.5%) BID for six weeks in patients with open-angle glaucoma or ocular hypertension. For patients not achieving target IOP at 6 weeks, a prostaglandin is added for another 6 weeks. |
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| D012898 |
| Autacoids |
| D018836 | Inflammation Mediators |
| D001685 | Biological Factors |