Simvastatin Reduces Adiponectin Levels and Insulin Sensitivity

Phase 4 Study of Simvastatin That Affects Insulin Sensitivity

We hypothesized simvastatin may reduce adiponectin levels and insulin sensitivity in overweight hypercholesterolemic patients.

Inclusion Criteria:

• Low-density lipoprotein cholesterol levels more than 100 and body mass index more than 23.0

Exclusion Criteria:

• Patients with overt liver disease
• Chronic renal failure
• Hypothyroidism, myopathy
• Uncontrolled diabetes
• Severe hypertension, stroke
• Acute coronary events
• Coronary revascularization within the preceding 3 months, or
• Alcohol abuse.