This 2 arm study will assess the impact of Bone Marker Feedback (BMF), using blood sampling and communication of the results at 2 months, on adherence to monthly Bonviva (150mg po) in women with post-menopausal osteoporosis. Patients will be randomized into either 1) a group which receives bone marker feedback or 2)a group which does not receive feedback on the results. The study will also assess patient satisfaction with treatment with once monthly Bonviva. The anticipated time on study treatment is 3-12 months, and the target sample size is 500+ individuals.

Inclusion Criteria:

• ambulatory post-menopausal women with osteoporosis;
• 55-85 years of age;
• eligible for bisphosphonate treatment;
• naive to bisphosphonate therapy, or lapsed users (last bisphosphonate intake > 6 months ago).

Exclusion Criteria:

• inability to stand or sit in an upright position for at least 60 minutes;
• inability to swallow a tablet whole;
• hypersensitivity to bisphosphonates;
• administration of any drug, or presence of active disease, known to influence bone metabolism;
• uncorrected hypocalcemia or other bone disturbances of bone and mineral metabolism;
• history of major upper gastrointestinal disease.