Efficacy and Safety of Levocetirizine and Fexofenadine in Reducing Symptoms of Seasonal Allergic Rhinitis

Trial to Compare the Efficacy and Safety of Levocetirizine 5 mg od and Fexofenadine 120 mg od in Reducing Symptoms of Seasonal Allergic Rhinitis in Grass Pollen Sensitized Adults

No information was yet available over the effect of levocetirizine in children under 12 years. The aim of this double-blind, placebo-controlled study was to assess the efficacy and safety of levocetirizine in children from 6 to 12 years old with perennial allergic rhinitis due to house dust mites.

Inclusion Criteria:

• adults 18 to 55 years both inclusive
• suffering at least 2 years of seasonal allergic rhinitis due to grass pollen
• positive RAST and/or positive skin prick test
• comply with study restrictions

Exclusion Criteria:

• known alcohol or drug addiction or abuse
• known allergy/intolerance to lactose, cellulose, cornstarch
• presence of nasal anatomical deformities leading to > 50% obstruction
• ENT infection within 30 days of the study
• use of disallowed medication
• ongoing desensitization
• known cardiac, renal or hepatic dysfunction
• presenting allergic bronchial asthma
• use of cimetidine
• intending to donate blood during the trial