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| ID | Type | Description | Link |
|---|---|---|---|
| SNF Grant. 3200-065588.04/1 |
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Context: Cholecystokinin (CCK) and neurotensin are stimulated during meal intake by the presence of fat in the small intestine. The sequence of events suggests that fat hydrolysis is crucial for triggering the release.
Objectives: The aim of this study was therefore to investigate whether CCK mediated the effect of intraduodenal (ID) fat on neurotensin secretion via CCK-1 receptors.
Setting: Single center study; 34 male volunteers were studied in consecutive, randomized, double blind, crossover studies.
Subjects and Methods: CCK and neurotensin release were quantified in: 1) 12 subjects receiving an ID fat infusion with or without 60 mg orlistat, an irreversible inhibitor of gastrointestinal lipases, in comparison to vehicle. 2) 12 subjects receiving ID long chain fatty acids (LCF), ID medium chain fatty acids (MCF) or ID vehicle. 3) 10 subjects receiving ID LCF with and without the CCK-1 receptor antagonist dexloxiglumide (DEXLOX) or ID vehicle plus IV saline (placebo). Hormone concentrations were measured by specific RIA systems.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| A, 3; B, 3; C, 3 | Other | A, 3: Fat with and without orlistat or placebo. B, 3: LCF vs MCF vs placebo. C, 3: LCF with and without DEXLOX or placebo. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fat perfusion to the small intestine | Dietary Supplement |
|
| Measure | Description | Time Frame |
|---|---|---|
| Neurotensin plasma concentrations | Change in plasma cocnentrations over 2-3 hours |
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Inclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Juergen Drewe, MD | University Hospital, 4031 Basel, Switzerland | Principal Investigator |
| Christoph Beglinger, MD | Department of Research and Clinical Pharmacology, University Hospital, Basel Switzerland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinical Research Center, University Hospital | Basel | CH-4031 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 3840906 | Background | Ferris CF, Carraway RE, Hammer RA, Leeman SE. Release and degradation of neurotensin during perfusion of rat small intestine with lipid. Regul Pept. 1985 Oct;12(2):101-11. doi: 10.1016/0167-0115(85)90191-0. |
| Label | URL |
|---|---|
| publication in JCEM | View source |
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