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| Name | Class |
|---|---|
| Allergopharma GmbH & Co. KG | INDUSTRY |
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We wanted to examine the immunogenicity and safety of a shortened specific immunotherapy in contrast to the standard specific immunotherapy.
Therefore, we challenged 12 patients for 14 weeks with the standard specific scheme and 22 patients for 6 weeks with the shortened scheme.
see above
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | Standard specific immunotherapy: Novo-Helisen Depot, Allergopharma Inc., Reinbek, Germany |
|
| 2 | Active Comparator | Shortened specific immunotherapy: Novo-Helisen Depot, Allergopharma Inc., Reinbek, Germany |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| specific subcutaneous immunotherapy house dust mite allergoid (Novo-Helisen Depot) | Biological | We treat each patient with mite-allergen following the two different protocols. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Safety of the shortened specific immunotherapy. | may 2004 - march 2005 |
| Measure | Description | Time Frame |
|---|---|---|
| Exhaled nitric oxid (eNO) and immunogenicity (IgE, specific IgE, specific IgG) in both groups. | may 2004 - march 2005 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stefan Zielen, M.D., Ph.D. | Goethe University, Department of Pulmonology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Goethe University, Department of Pulmonology | Frankfurt am Main | Hesse | 60590 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12915987 | Background | Hansen I, Hormann K, Stuck BA, Schneider-Gene S, Mosges R, Klimek L. [Cluster-immunotherapy in seasonal allergic rhinitis: safety aspects of induction therapy with depot allergoids (Purethal)]. Laryngorhinootologie. 2003 Aug;82(8):558-63. doi: 10.1055/s-2003-41234. German. | |
| 15990782 | Background | Tabar AI, Echechipia S, Garcia BE, Olaguibel JM, Lizaso MT, Gomez B, Aldunate MT, Martin S, Marcotegui F. Double-blind comparative study of cluster and conventional immunotherapy schedules with Dermatophagoides pteronyssinus. J Allergy Clin Immunol. 2005 Jul;116(1):109-18. doi: 10.1016/j.jaci.2005.05.005. |
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|
| ID | Term |
|---|---|
| D001249 | Asthma |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012130 | Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
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| ID | Term |
|---|---|
| C014135 | Novo-Helisen Depot |
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