Changes in Retinal Function After Intravitreal Ranibizumab for Age-related Macular Degeneration

Electrophysiologic Changes After Intravitreal Ranibizumab (Lucentis) for Age-related Macular Degeneration

Age-related macular degeneration, a leading cause of blindness, is caused by an abnormal growth of the vessels beneath the retina. Ranibizumab (Lucentis) is a new drug that inhibits the growth of new vessels and has recently been approved by FDA for treating this condition. This study is carried out to evaluate the changes in retinal function after an injection of ranibizumab.

The functional changes of the retina can be recorded by an electroretinography (ERG).

Inclusion Criteria:

• Age 45 years and above
• Clinical diagnosis of wet AMD
• First injection of ranibizumab protocol
• Best corrected visual acuity 20/32 - 20/320
• Consent form obtained

Exclusion Criteria:

• Previously treated wet AMD patients
• Patients with other ocular diseases which can cause abnormal ERG such as glaucoma, uveitis or retinitis pigmentosa, etc.
• Pregnancy
• History of seizure