Comparative Study of Influenza Vaccines in Adults, FLUVACS-year 4

Comparative Study of Influenza Vaccines in Adults, FLUVACS-year 4

The purpose of this study is to evaluate the absolute (versus placebo) and relative (one vaccine compared to the other) efficacies of the live attenuated and inactivated influenza vaccines in preventing laboratory confirmed symptomatic influenza caused by circulating strains whether similar or dissimilar to strains included in the vaccines.

Inclusion Criteria:

• Healthy adult men and women
• Age 18-49 years
• Who reside geographically close to one of the four study sites in Michigan

Exclusion Criteria:

• Persons with any of the health conditions for which the inactivated vaccine is recommended
• Persons for whom either vaccine is contraindicated