The definition of pulmonary candidiasis is still unclear.In China, isolation of candida spp. form sputum twice or three times a week has been regarded as the microbiological evidence of pulmonary candidiasis. The investigators hypothesize that patients who present respiratory symptoms and lung infiltrates together with smear of culture positive for candida spp. from sputum three times a week can not be diagnosed as pulmonary candidiasis.

Inclusion Criteria:

• 85ys>age>14ys
• APACHE II<25
• Lung infiltrates together with at least one of the following symptoms:cough, sputum, dyspnea with or without fever
• smear or culture positive for candida spp. from sputum

Exclusion Criteria:

• Pregnancy
• Hypersensitivity to fluconazole
• Isolated candida was non-sensitive to fluconazole
• Severe liver or renal diseases who can not tolerate fluconazole treatment
• With at least one of the following high risk factors:organ transplantation, neutropenia>10ds, long term glucocorticoids therapy(equal to prednisone 30mg/d longer than 2 weeks), immunosuppressive therapy within 30ds, AIDS
• With one of the microbiological evidence:isolation of candida spp. from blood or other kinds of sterile site(not including urine), filamentous fungi isolated from sputum or BALF, cryptococcus isolated from sputum or CSF, galactomannan antigen positive twice for blood
• Probable or possible pulmonary aspergillosis
• Definite oral or esophageal candidiasis