This is a first time in human study that is being done to determine the maximum tolerated dose and initial pharmacokinetic parameters of GSK461364, given by IV, in adult subjects with solid tumors and Non-Hodgkins lymphoma.

Inclusion Criteria:

• Confirmed diagnosis of advanced solid tumor or Non-Hodgkins Lymphoma (excluding HIV-associated lymphoma) that has relapsed or is refractory to standard therapies
• At least 18 years of age
• Female who are of non-childbearing potential or who have a negative pregnancy test who uses approved contraception
• Male with a female partner of childbearing potential must have had a vasectomy or both are using approved contraception
• Lab values that are within range as described in the protocol
• Paraffin-embedded archival tumor tissue available for testing
• Signed written informed consent

Exclusion Criteria:

• Undergone major surgery or received anti-cancer therapy
• History of hemolytic anemia
• Clinical lab tests that are out of range as described in the protocol
• Females who are pregnant or lactating
• Significant heart problems
• Serious or unstable pre-existing medical or psychiatric condition
• Are not able to comply with the study protocol
• Use of prohibited medications
• Have low blood pressure
• Evidence of symptomatic or untreated central nervous system involvement and require corticosteroids or anti-epileptic meds

Patient-level data for this study will be made available through www.clinicalstudydatarequest.com following the timelines and process described on this site.