Treatment of Disseminated High Grade Lymphoma

Phase III Study of Treatment of Disseminated and Agressive Lymphoma R CHOP Versus R CLOP( With Liposomal Doxorubicin)

Interest of the use of pegylated liposomal doxorubicin (caélyx)

R CHOP is a good standard in the treatment of diffuse high grade lymphoma. Howeverin elderly patients it is often toxic, specially with haematologic and cardiac toxicities.

Inclusion Criteria:

• high grade lymphoma
• disseminated
• > 60 years old and < 75
• informed consent signed
• cardiac state compatible with antracyclin
• ECOG </= 2

Exclusion Criteria:

• patients > 75 years old
• Cardiac insufficiency