Prevention of Preterm Delivery With Vaginal Progesterone in Women With Preterm Labor
Prevention of Preterm Delivery With Vaginal Progesterone in Women With Preterm Labor
The administration of vaginal progesterone, in addition to standard tocolysis, will decrease the risk of delivering prematurely and of recurrent preterm labor. We also hypothesize that the reduction in preterm delivery will be associated with a decrease in infant mortality and morbidity.
The principal aim is to demonstrate that progesterone reduces preterm birth before 37 weeks of gestation. Secondary aims are to show that progesterone 1) reduces preterm birth before 32 and before 34 weeks of gestation 2) reduces the number and duration of recurring episodes of preterm labor and 3) reduces infant mortality and morbidity.
Inclusion Criteria:
Gestational age between 240/7 et 336/7 weeks of gestation (based on a reliable estimate by ultrasound performed before 22 weeks)
Singleton pregnancy
Intact membranes
Preterm labor defined as:
Age ≥ 18 years old
Signed informed consent
Possible and accepted follow-up
Exclusion Criteria:
Buenos Aires, Alem 349, Ezeiza, Provincia de Buenos Aires, Argentina
Buenos Aires, Av. Diaz Velez 5044, Cuidad Autónoma de Buenos Aires, Argentina
Buenos Aires, Av. E. Galván 4102, Ciudad Autónoma de Buenos Aires, Argentina
Buenos Aires, Av. Las Heras 2670, Cuidad Autónoma de Buenos Aires, Argentina
Buenos Aires, Av. Libertador 710, Moreno, Provincia de Buenos Aires, Argentina
Buenos Aires, Av. Mate de Luna 1555, Provincia de Tucumán, Argentina
Buenos Aires, Diego Palma 505, San Isidro, Provincia de Buenos Aires, Argentina
Buenos Aires, Dr. Félix Pagola 1502, Zárate, Provincia de Buenos Aires, Argentina
Buenos Aires, Dr. Juan Felipe Aranguren 2701, Cuidad Autónoma de B.A., Argentina
Buenos Aires, Esteban de Luca 2151, Ciudad Autónoma de Buenos Aires, Argentina
Buenos Aires, Iparaguirre Nº 239, Pte. Derqui, Provincia de Buenos Aires, Argentina
Buenos Aires, Juan D. Perón 4190, Ciudad Autónoma de Buenos Aires, Argentina
Buenos Aires, Monte 848, Morón, Provincia de Buenos Aires, Argentina
Buenos Aires, Pilar 950, Ciudad Autónoma de Buenos Aires, Argentina
Buenos Aires, Py Y Margall 750, Cuidad Autónoma de Buenos Aires, Argentina
Buenos Aires, Ramón Carillo 1339, Rafael Calzada, Provincia de Buenos Aires, Argentina
Buenos Aires, Ricardo Balbín 1910, Merlo, Provincia de Buenos Aires, Argentina
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Buenos Aires, Ruta 8Km. 20,5 N°9100, Loma Hermosa, Provincia de Buenos Aires, Argentina