A Clinical Study to Evaluate the Pharmacokinetic Profile of SB-649868 in Elderly and Female Population

A Single-centre, Open Label, Single-dose, Four Parallel Cohorts Study to Investigate the Pharmacokinetics, Safety and Tolerability of SB-649868 10mg in Healthy Female "Non-childbearing Potential", Healthy Male and in Healthy Elderly Subjects

The purpose of this study is to determine the blood levels and the tolerability of SB-649868 in Elderly and Female population

INCLUSION CRITERIA:

• Healthy adult and elderly female and male
• Female must be of non-childbearing potential
• Body weight =50 kg

EXCLUSION CRITERIA:

• Abuse of alcohol or drugs
• Positive for Hepatitis B surface antigen, Hepatitis C antibody or HIV
• Use of prescription or non-prescription drugs within 7 days prior to the first dose of study medication
• Smoking history of = 10 cigarettes a day in the last three months
• History of cardiovascular,psychiatric,autoimmune, respiratory or relevant gastrointestinal diseases
• Participation in clinical trial during the previous 6 months