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The purpose of this study is to test how vinflunine interacts with rifampin in the human body
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vinflunine | Drug | |||
| Rifampin | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| The Primary Outcome Measure of the effect of rifampin on the pharmacokinetics (PK) of intravenous (IV) vinflunine will be determined from the PK measurements | taken during Cycle 2 of study treatment, at approximately 4 weeks after the start of study treatment |
| Measure | Description | Time Frame |
|---|---|---|
| The Secondary Outcome Measures of the safety and tolerability of vinflunine when administered alone and with rifampin | determined after 2 complete 21-day Cycles of study treatment, at approximately 6 weeks after the start of study treatment |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Local Institution | Detroit | Michigan | 48201 | United States |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| C111217 | vinflunine |
| D012293 | Rifampin |
| ID | Term |
|---|---|
| D012294 | Rifamycins |
| D006576 | Heterocyclic Compounds, 4 or More Rings |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
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| D047029 | Lactams, Macrocyclic |
| D047028 | Macrocyclic Compounds |
| D011083 | Polycyclic Compounds |