The ROVO Study: Radial Optic Neurotomy for CVO

A Multicenter Trial for Surgical Treatment of Central Retinal Vein Occlusion - Radial Optic Neurotomy for CVO The ROVO Study

The ROVO study is a prospective, placebocontrolled and randomised study designed to evaluate the effect of radial optic neurotomy in central vein occlusion, versus triamcinolone acetonide. 240 patients with a visual acuity < 0.5 Snellen will be randomised. Patients are treated with either RON, or a single intravitreal injection of 4 mg triamcinolone acetonide, or a placebo treatment - a "sham" injection of intravitreal triamcinolone. Patients will be examined regularly over a period of one year.

Best corrected visual acuity for far and near, as well as clinical examinations, fluorescein- and indocyanine green angiograms, optical coherence tomography, and perimetry, are performed pre- and postoperatively.

Inclusion Criteria:

• Onset of CVO not longer than 12 months
• On FLA 1. nonperfused - (greater than 10 disc area of nonperfusion) 2. perfused - visual acuity lower than 0.1 Snellen,or 3. perfused with no improvement of visual acuity over 4 weeks)

Exclusion Criteria:

• • Dense cataract* (grade 3 and 4) which precludes judgement of the fundus.

  • Pregnancy
  • Allergy against Fluoresceine or Indocyanine green
  • Unable to come for follow up visit
  • Presence of other severe retinopathy or
  • Presence of advanced optic atrophy or uncontrolled glaucoma.
  • Visual acuity higher than 0.5 Snellen.