Efficacy, Safety of Hypertonic Lactate Soln. as Fluid Resuscitation Compared With Ringer's Lactate in Post-CABG Pats

The Efficacy and Safety of Hypertonic Lactate Solution as Fluid Resuscitation Compared With Ringer's Lactate in Post-CABG (Coronary Artery Bypass Grafting) Patients

Prospective, randomized, open-label study to assess the efficacy and safety of hypertonic lactate solution, compared to Ringer's Lactate as fluid resuscitation to maintain hemodynamic stability in post-coronary artery bypass grafting(CABG) patients. Patients who were eligible received either hypertonic lactate solution or Ringer's Lactate post-CABG in the ICU when fluid resuscitation was needed.

Prospective, randomized, open-label study to assess the efficacy and safety of hypertonic lactate solution, compared to Ringer's Lactate as fluid resuscitation to maintain hemodynamic stability in post-coronary artery bypass grafting(CABG) patients. Patients who were eligible received either hypertonic lactate solution or Ringer's Lactate post-CABG observed in the first 12 hours in the ICU when fluid resuscitation was needed.

Inclusion Criteria:

• Patients who have given their written informed consent.
• Male or female, aged 18-75 years.
• Post-operative CABG on pump or off pump in ICU.
• Patients who need fluid resuscitation.

Exclusion Criteria:

• Combined operations.
• Need for intra aortic balloon pump (IABP).
• Patients with severe arrhythmia (VT, AF rapid response, heart block).
• Severe hemodynamic imbalance.
• Severe bleeding and/or re-operation.
• Liver dysfunction(SGOT and SGPT 2x normal).
• Renal failure (Creatinine >2 mg%).