Acute Effects of Sildenafil on Endothelial Function in People With Diabetes

Acute Effects of Sildenafil on Flow Mediated Dilatation and Cardiovascular Autonomic Nerve Function in Type 2 Diabetic Patients

This is a double-blind, placebo-controlled, cross-over trial using a single dose of 100 mg sildenafil or placebo in 40 subjects with T2DM without known cardiovascular disease. Effects on haemodynamic parameters, flow mediated dilatation (FMD) in brachial artery, cardiovascular autonomic function tests, and spontaneous baroreflex sensitivity (BRS) were investigated.

Inclusion Criteria:

• age 35-70
• type 2 diabetes mellitus
• impotence
• with and without hypertension, hypercholesteremia

Exclusion Criteria:

• patients with history of cardiovascular and malignant disease,
• advanced nephropathy (creatinine≥2.2mg/dl)
• hepatopathy (liver enzymes higher than the double of normal values)
• patients taking nitrates
• CHF: NYHA > II
• Stable angina: CCS > II