The purpose of this study is to determine if the overall fluid requirements for the first 24 hours after admission will be reduced with Hextend versus a standard of care crystalloid resuscitation fluid.

Following severe multi-system traumatic injury, the first 24 hours of standard resuscitation fluid will be either Hextend or crystalloid depending upon attending preference. No tests or interventions will be performed for research purposes.

Data will be collected prospectively from patient medical records and attending clinicians to monitor fluid requirements, hemodynamics and outcome.

Inclusion Criteria:

• Greater than or equal to 18 years old and less than 65 years old
• Admission with multi-system traumatic injury
• Admission to the intensive care unit

Exclusion Criteria:

• Less than 18 or greater than 65 years old
• Pregnant or lactating
• No fluid resuscitation

Adult Trauma Patients

Adverse events were not collected for this observational study.