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| ID | Type | Description | Link |
|---|---|---|---|
| R01NR009228 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Nursing Research (NINR) | NIH |
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Patients recovering from coronary artery bypass graft (CABG) surgery have high rates of depression, and depression is associated with higher risk of complications and death. Recent discoveries show that depression involves changes in certain molecules in the blood, which are also involved in progressive coronary artery disease (CAD) and its complications. This study will evaluate the effects of cognitive behavioral therapy (CBT) as a treatment for depression on these biological markers among CABG patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental |
| |
| 2 | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cognitive Behavioral Therapy (CBT) | Behavioral | Subjects receive CBT in the home for 8 weeks with blood draws every other week during therapy. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Levels of proinflammatory cytokines (IL-1 and IL-6) | at baseline and after 8 weeks (at the completion of the intervention) | |
| The soluble receptor for IL-6 (sIL-6) | at baseline and after 8 weeks (at the completion of the intervention) | |
| Inflammatory markers c-reactive protein (CRP and sICAM-1) | at baseline and after 8 weeks (at the completion of the intervention) |
| Measure | Description | Time Frame |
|---|---|---|
| Depression symptoms (Beck Depression Inventory) | at baseline and after 8 weeks (at the completion of the intervention) | |
| Presence of clinical depression | at baseline and after 8 weeks (at the completion of the intervention) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Lynn Doering, RN, DNSc | University of California, Los Angeles | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Long Beach Memorial Medical Center | Long Beach | California | 90806 | United States | ||
| Cedars-Sinai Medical Center |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24979578 | Derived | Doering LV, Chen B, McGuire A, Bodan RC, Irwin MR. Persistent depressive symptoms and pain after cardiac surgery. Psychosom Med. 2014 Jul-Aug;76(6):437-44. doi: 10.1097/PSY.0000000000000074. | |
| 24763358 | Derived | Hwang B, Eastwood JA, McGuire A, Chen B, Cross-Bodan R, Doering LV. Cognitive behavioral therapy in depressed cardiac surgery patients: role of ejection fraction. J Cardiovasc Nurs. 2015 Jul-Aug;30(4):319-24. doi: 10.1097/JCN.0000000000000155. |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| D003863 | Depression |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D015928 | Cognitive Behavioral Therapy |
| ID | Term |
|---|---|
| D001521 | Behavior Therapy |
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |
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| Usual Care | Behavioral | Subjects receive Usual Care for 8 weeks followed by CBT |
|
| Pain | at baseline and after 8 weeks (at the completion of the intervention) |
| Sleep disturbances | at baseline and after 8 weeks (at the completion of the intervention) |
| Los Angeles |
| California |
| 90027 |
| United States |
| Kaiser Permanente Medical Center - Sunset | Los Angeles | California | 90027 | United States |
| Department of Veterans Affairs-Greater Los Angeles Healthcare System, West Los Angeles | Los Angeles | California | 90073 | United States |
| University of California, Los Angeles School of Nursing | Los Angeles | California | 90095 | United States |
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |