Role of Regulatory T Cells in Pathogenesis of Primary IgA Nephropathy

Role of CD4+CD25+FoxP3+ Regulatory T Cells in Pathogenesis of Primary IgA Nephropathy

Along structural IgA abnormalities, hyperproduction of IgA is thought to play a role in the pathogenesis of primary IgA nephropathy. CD4+CD25+Fox3P regulatory T cells are instrumental in suppressing adaptative immune responses, including B cells production of immunoglobulins. We, the researchers at Centre Hospitalier Universitaire de Saine Etienne, will test the hypothesis that IgA production in patients with IgA nephropathy is dysregulated because of a quantitative and/or qualitative defect of CD4+CD25+FoxP3+ regulatory T cells.

Inclusion Criteria:

• Patients with pathogenesis of Berger's disease confirmed by renal biopsy
• Glomerular filtration > 60 ml/min/1,73m2
• Written informed consent
• Patient affiliated to social insurance

Exclusion Criteria:

• Immunosuppressor treatment within 6 months before the study inclusion
• Clinical infection within 2 months before the study inclusion
• C-reactive protein (CRP) > 10 mgL-1