Phase 2, Multi-Center Trial of Modafinil for Methamphetamine Dependence

Phase2, Double-blind, Placebo-controlled Trial of Modafinil for the Treatment of Methamphetamine Dependence

The purpose of this study will be to examine the safety and efficacy of modafinil in increasing number of methamphetamine non-use weeks in subjects with methamphetamine dependence.

To evaluate the efficacy and safety of modafinil in reducing methamphetamine use in subjects with methamphetamine dependence. It is hypothesized that modafinil, compared to placebo, will be associated with an increase in the number of methamphetamine non-use weeks over time as measured by quantitative urine analysis for methamphetamine.

Inclusion Criteria:

• Must be between the ages of 18 and 65
• Methamphetamine dependent as defined by DSM-IV criteria
• Must be in good general heath with a history of methamphetamine use at screening
• Must be able to provide written informed consent
• If female and of child bearing potential, must agree to use birth control.

Exclusion Criteria:

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